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Article
February 1981

`Essential' Cryoglobulinemia: Follow-up Evaluation of Case Findings 28 Years Later

Arch Dermatol. 1981;117(2):65. doi:10.1001/archderm.1981.01650020005008
Abstract

To the Editor.—  The following patient was first described in the Archives in March 1953 (67:429-430) as a case of "essential" cryoglobulinemia. Follow-up evaluation was obtained in the course of a retrospective review of 40 patients with this syndrome seen at our medical center during the past 20 years.1 This case illustrates the coexistence of clinical features of systemic vasculitis and lymphoproliferative disease in some patients with serum cryoglobulins.

Report of a Case.—  A 33-year-old woman had recurrent purpura and arthralgias develop three years earlier during pregnancy. The rash was aggravated by cold exposure and initially involved the legs but later spread to the arms and buttocks. A skin biopsy specimen showed leukocytoclastic angiitis. Eventually, a left lateral malleolar leg ulcer developed, but the condition responded gradually to bed rest. Two years previously, hepatosplenomegaly had been noted. A liver biopsy specimen indicated portal infiltration by lymphocytes and plasma cells, consistent

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