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February 1981

Abnormalities of Immunoregulation in Progressive Systemic SclerosisEvidence for Excess Helper-Cell Function and Altered B-Cell Function

Author Affiliations

From the Departments of Rheumatic and Immunologic Disease (Drs Krakauer, Sundeen, and Scherbel) and Dermatology (Dr Sauder), The Cleveland Clinic Foundation. Dr Sauder is now with the National Cancer Institute.

Arch Dermatol. 1981;117(2):80-82. doi:10.1001/archderm.1981.01650020022017

• We investigated immunoregulatory function in patients with progressive systemic sclerosis (PSS) in terms of in vitro IgM synthesis. Suppressor-cell function seems normal in regard to the ability of concanavalin A—treated cells to inhibit IgM synthesis by normal cells. At 4 × 105 T cells to 3 × 105 allogeneic normal B cells per milliliter, T cells from patients with PSS induce significantly more IgM synthesis by normal B cells than do normal T cells. This increased helper T-cell function might be involved in the pathogenesis of the disease.

(Arch Dermatol 117:80-82, 1981)