• We investigated immunoregulatory function in patients with progressive systemic sclerosis (PSS) in terms of in vitro IgM synthesis. Suppressor-cell function seems normal in regard to the ability of concanavalin A—treated cells to inhibit IgM synthesis by normal cells. At 4 × 105 T cells to 3 × 105 allogeneic normal B cells per milliliter, T cells from patients with PSS induce significantly more IgM synthesis by normal B cells than do normal T cells. This increased helper T-cell function might be involved in the pathogenesis of the disease.
(Arch Dermatol 117:80-82, 1981)
Krakauer RS, Sundeen J, Sauder DN, Scherbel A. Abnormalities of Immunoregulation in Progressive Systemic SclerosisEvidence for Excess Helper-Cell Function and Altered B-Cell Function. Arch Dermatol. 1981;117(2):80-82. doi:10.1001/archderm.1981.01650020022017