Hodgkin's disease (HD) may exhibit cutaneous manifestations in about 25% of the cases. Nonspecific involvement including pruritus and prurigo, eczematous eruptions, exfoliative dermatitis, pigmentation, alopecia, and ichthyosis is most commonly seen. Specific papular, nodular, and ulcerative skin lesions are also seen, but much less frequently.
A patient had an unusual eczematoid dermatitis that showed the histologic features of palisading necrobiotic granuloma associated with HD. To our knowledge, this is the first case of this manifestation reported in the literature.
Report of a Case
A 68-year-old man was referred to us in June 1979 with increasing malaise, anorexia, arthralgias, and a pruritic dermatitis that had spread from the legs to the upper parts of the trunk and arms during the previous eight months. He had a medical history of psoriasis of the feet, toenails, and fingernails, chronic obstructive pulmonary disease, and hypertension. His medications included prednisone and a thiazide diuretic.Initial
Peltier FA, Pursley TV, Apisarnthanarax P, Raimer SS. Necrobiotic Granulomas of the Skin Associated With Hodgkin's Disease. Arch Dermatol. 1981;117(2):123-124. doi:10.1001/archderm.1981.01650020065032