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Dr Armstrong suggests that the findings in our study relating to decreased response to DNCB in chronic sun-damaged skin may be caused by differences in the carrier protein to which the DNCB had been bound rather than by decreased cell-mediated immunity to the DNCB-protein complex.This alternative hypothesis may be correct. It does, however, ignore the problem of decreased responses to intradermal injection of mumps, Candida, and a tuberculosis antigen. Although it is possible that the same altered carrier could be involved in reactions to all four antigens, I believe this would be unlikely. In any event, Dr Armstrong's alternative explanation offers more opportunities for further study.
Smith EB. Diminished Immune Response in Sun-Damaged Skin-Reply. Arch Dermatol. 1981;117(3):128. doi:10.1001/archderm.1981.01650030004005