Tymphomatoid papulosis is a cutaneous reaction pattern characterized by self-healing asymptomatic papules, a histologic picture of malignant-appearing mononuclear cells, and a benign clinical course.
We describe herein a woman with a 20-year history of lymphomatoid papulosis that was misdiagnosed both clinically and histologically as insect bites, primarily because of the unusual histologic finding of a large number of eosinophils admixed with the atypical cells characteristic of lymphomatoid papulosis.
Report of a Case
A 53-year-old woman was first seen in consultation in March 1979, when she was admitted to the hospital for medical evaluation of unstable angina pectoris. She had had a 20-year history of asymptomatic papules that waxed and waned, with individual lesions persisting for approximately two weeks. No variation in this course was noted with change in season or geographic locale. During this 20-year interval, physicians had ascribed the lesions to "allergic reactions or bites," although no biopsy specimen
Moreland ME, Johnson WT. Lymphomatoid Papulosis With Eosinophilia. Arch Dermatol. 1981;117(3):181-182. doi:10.1001/archderm.1981.01650030059019