A recent case of a patient with Hodgkin's disease, seminoma of the testicle, and widespread granuloma annulare (GA) raised the possibility of an association between Hodgkin's disease and GA.1 We describe here two patients with Hodgkin's disease in whom GA developed.
Report of Cases
A 57-year-old woman had, in the spring of 1976, a large glandular swelling in the right inguinal area. A biopsy specimen showed Hodgkin's disease of the nodular sclerosing type. Staging evaluation included lymphangiography; abdominal exploration determined that she had stage IIB disease. While undergoing radiotherapy, an enlarged supraclavicular node developed, which, on biopsy, showed the nodular sclerosing pattern. The cancer stage was changed to IIIB. From October 1976 to March 1977, she was treated with intermittent combined chemotherapy (mechlorethamine hydrochloride, vincristine sulfate [Oncovin], procarbazine hydrochloride, and prednisone) (MOPP). She had remained free of evidence of Hodgkin's disease since that time.In September 1979,
Schwartz RA, Hansen RC, Lynch PJ. Hodgkin's Disease and Granuloma Annulare. Arch Dermatol. 1981;117(3):185-186. doi:10.1001/archderm.1981.01650030063022