• The effect of clemastine fumarate, a histamine H1-antagonist, on the potentiation of itch by prostaglandin E1 (PGE1) was studied in normal humans. The antihistamine drug did not abolish the potentiation, which suggests that the effect of PGE1 on itch does not depend on the liberation of endogenous histamine.
(Arch Dermatol 1981;117:208-209)
Boss M, Burton JL. Lack of Effect of the Antihistamine Drug Clemastine on the Potentiation of Itch by Prostaglandin E1. Arch Dermatol. 1981;117(4):208-209. doi:10.1001/archderm.1981.01650040024013