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April 1981

Anti-Pigment-Cell Factors and Mucocutaneous Candidiasis

Author Affiliations

From the Department of Dermatology, West Haven (Conn) Veterans Administration Medical Center (Dr Nordlund); the Department of Dermatology, Yale University School of Medicine, New Haven, Conn (Ms Forget and Dr Lerner); and the New York University Medical Center (Drs Howanitz and Bystryn).

Arch Dermatol. 1981;117(4):210-212. doi:10.1001/archderm.1981.01650040026014

• Previous reports document the fact that some patients with mucocutaneous candidiasis and vitiligo have a complementfixing anti-pigment-cell factor in their serum. We examined sera from seven patients with mucocutaneous candidiasis without vitiligo. Three of the seven sera contained the anti-pigment-cell factor. We suggest that these anti-pigment-cell factors, which are most probably antibodies, are not cytotoxic for pigment cells and, thus, not the cause of vitiligo. The association of vitiligo and anti-pigment-cell factors with the syndrome of mucocutaneous candidiasis implicates the immune system as a causal factor of vitiligo.

(Arch Dermatol 1981;117:210-212)