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April 1981

Scale ProphylaxisA New Antiparakeratotic Assay

Author Affiliations

From the Department of Dermatology, University College Hospital Medical School, London. Dr Wrench is now with Wolfson College, Cambridge, England.

Arch Dermatol. 1981;117(4):213-215. doi:10.1001/archderm.1981.01650040029015

• This article describes a new animal model for the evaluation of drugs that may prevent the development of parakeratosis. The advantages of this model are simplicity, economy, and the opportunity to observe the possible occurrence of acute systemic toxic reactions. High-boiling coal tar acids (phenols), vitamin A (retinyl acetate), and hydrocortisone butyrate (Locoid) were assayed. Only tar phenols consistently prevented scale development. Vitamin A was not properly screened because of toxic effects that resulted in premature termination of the experiment.

(Arch Dermatol 1981;117:213-215)