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Article
May 1981

Cutaneous Involvement in Malignant HistiocytosisCase Report and Review of the Literature

Author Affiliations

From The Johns Hopkins Oncology Center (Drs Marshall and Trump) and the Department of Dermatology (Dr Farmer), The Johns Hopkins Medical Institutions, Baltimore.

Arch Dermatol. 1981;117(5):278-281. doi:10.1001/archderm.1981.01650050034017
Abstract

• Malignant histiocytosis (MH) is a rare, malignant neoplasm with protean manifestations, including fever, lymphadenopathy, hepatosplenomegaly, pancytopenia, and, infrequently, cutaneous lesions. A patient had initial manifestations that included fever and skin lesions. Skin lesions began on distal areas of the extremities and spread to involve proximal areas of the extremities and the abdomen. Erythematous maculopapular lesions, nodules, and plaques were present in various stages of development, which evolved into ulcerated plaques that exuded a serosanguineous discharge. Spontaneous healing of lesions occurred, leaving hyperpigmented, atrophic scars. Histologically, the deep dermis and subcutaneous tissues contained a diffuse infiltrate of histiocytes, lymphocytes, and mononuclear cells. Erythrophagocytosis by histiocytes was present in the skin biopsy material. Thirteen percent of 320 cases in the literature had skin involvement. This report and review of the literature indicate that, in selected cases, skin biopsy may contribute to the diagnosis of MH.

(Arch Dermatol 1981;117:278-281)

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