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Article
May 1981

Cutaneous Alternariosis Treated With Miconazole

Author Affiliations

From the Departments of Dermatology (Dr de Moragas) and Microbiology (Dr Prats) and Infectious Diseases Unit (Dr Verger), Hospital de la Santa Cruz y San Pablo, Barcelona, Spain.

Arch Dermatol. 1981;117(5):292-294. doi:10.1001/archderm.1981.01650050048021
Abstract

• A 40-year-old man had had a chronic, slowly spreading inflammatory process in the skin over the right knee of ten years' duration. Culture of a biopsy specimen grew Alternaria sp. Antimycotic susceptibility testing with flucytosine, amphotericin B, and miconazole nitrate was performed. The Alternaria was highly sensitive to the last two drugs. Miconazole nitrate, 1.2 g daily intravenously for 31 days, did not induce a clinical response. The lesions were then infiltrated with 10 mg of miconazole nitrate in 10 mL of polyethoxylated castor oil (Cremophor EL) twice weekly, with clearing of the lesions during a several-month period.

(Arch Dermatol 1981;117:292-294)

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