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June 1981

Clinicopathologic Correlations in Alibert-type Mycosis Fungoides

Author Affiliations

From the Department of Dermatology, Abraham Lincoln School of Medicine, University of Illinois College of Medicine, Chicago. Dr Eng is now with Loyola University Medical Center, Maywood, Ill.

Arch Dermatol. 1981;117(6):332-337. doi:10.1001/archderm.1981.01650060022016

• Five cases of mycosis fungoides of the Alibert type were studied by taking multiple biopsy specimens at different stages of the disease. Large hyperchromatic, slightly irregular mononuclear cells are the most frequent cells. Ultrastructurally, the cells were only slightly convoluted, had prominent heterochromatin banding at the nuclear membrane, and unremarkable cytoplasmic organelles. Highly convoluted cerebriform nucleated cells were few. Large regular vesicular histiocytes were prominent in the early stages. Ultrastructurally, the cells showed evenly distributed euchromatin. Epidermotrophism was equally as important as Pautrier's abscess as a hallmark of the disease. Stereologic techniques comparing the infiltrate with regard to size and convolution of cells in all stages of mycosis fungoides with infiltrates seen in a variety of benign dermatoses showed no statistically significant differences.

(Arch Dermatol 1981;117:332-337)