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June 1981

Photoallergic Contact Dermatitis to Musk AmbretteHistopathologic Features of Photobiologic Reactions Observed in a Persistent Light Reactor

Author Affiliations

From the Departments of Dermatology (Drs Giovinazzo, Harber, Armstrong, and Silvers) and Pathology (Dr Silvers), College of Physicians and Surgeons, Columbia University, New York; and the Division of Dermatology (Dr Bickers), Case Western Reserve University, Cleveland.

Arch Dermatol. 1981;117(6):344-348. doi:10.1001/archderm.1981.01650060034019

• Studies concerning a patient with contact photosensitivity to musk ambrette, a commonly used fragrance, are reported. The patient had a persistent light reaction. The patient's history, clinical appearance, and phototest and photopatch test results are described. The observed patterns of these were identical to those previously noted in patients who had persistent light reactions after exposure to other photosensitizers such as the halogenated salicylanilides. The histopathologic findings in the phototest and photopatch test sites were those of an acute spongiotic dermatitis. No abnormal change was seen with ultraviolet A radiation exposure alone.

(Arch Dermatol 1981;117:344-348)