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Article
July 1981

Controversy in Genetic Disorders

Arch Dermatol. 1981;117(7):380. doi:10.1001/archderm.1981.01650070004003
Abstract

To the Editor.—  The July issue of the Archives contains two articles dealing with genetic diseases that suffer seriously from a lack of rigorous review of their genetic aspects.In their article entitled "Palmoplantar Keratoderma and Charcot-Marie-Tooth Disease" (1980;116:789-790), Rabbiosi et al describe a family with concomitant palmoplantar keratoderma (PPK) and Charcot-Marie-Tooth disease (CMT). According to them, all patients with PPK had CMT, and no patients without PPK had CMT. They claim that, therefore, both CMT and PPK are the expression of the same mutant allele.Careful review of the Table on page 790 of their article shows that none of the family members without PPK had electrophysiologic testing performed, despite the statement in the text that "in all individuals who were not affected with PPK, no electromyographic [EMG] abnormalities were demonstrable." In the same table, patient IV-4, who had PPK, has no electrophysiologic abnormalities. The text claims that all

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