Application of newly developed or refined laboratory techniques to a variety of diseases has often resulted in modification of time-honored clinical classifications. In the blistering diseases, the techniques of immunopathologic study and electron microscopy have provided the basis for more accurate diagnoses and more rational speculations on pathomechanisms. However, these accomplishments in no way relieve the investigator from the obligation to make careful clinical pathologic correlations to be certain that the new observations advance rather than retard our understanding of the diseases under study.
Epidermolysis bullosa acquisita (EBA) has been long established as a clinical entity, because its distinct clinical features are similar to those of inherited dermolytic epidermolysis bullosa. It is manifested by blisters that develop at sites of trauma, scarring, milia, oral mucous membrane lesions, and dystrophic nail changes. The only unique clinical features of EBA are the lack of inheritance and the appearance of the first lesions
Roenigk HH, Pearson RW. Epidermolysis Bullosa Acquisita. Arch Dermatol. 1981;117(7):383. doi:10.1001/archderm.1981.01650070011010