July 1981

Combined H1 and H2 Antihistamine Therapy in Chronic Urticaria

Author Affiliations

From the Sections of Dermatology (Drs Monroe and Schulz) and Allergy (Dr Cohen), Department of Medicine, Medical College of Wisconsin; the Research Service, Wood Veterans Administration Medical Center (Dr Kalbfleisch); and Milwaukee Medical Clinic SC (Dr Monroe), Milwaukee.

Arch Dermatol. 1981;117(7):404-407. doi:10.1001/archderm.1981.01650070032018

• Chronic urticaria is a frustrating problem for the patient and the physician. The cause is usually undetermined, and the therapy is directed toward controlling symptoms. Recent evidence that human skin blood vessels possess H2 receptors, as well as the commonly recognized H1 receptors, suggests a possible reason for the frequent failure of H1 antihistamines in controlling this disorder. Eighteen patients with refractory chronic idiopathic urticaria participated in a double-blind, cross-over study to evaluate the efficacy of combined H (hydroxyzine hydrochloride) and H2 (cimetidine) antihistamines vs H1 antihistamines alone. This study indicates that combined H1 and H2 antihistamine therapy is statistically more effective than H1 antihistamines alone in controlling the symptoms of chronic urticaria.

(Arch Dermatol 1981;117:404-407)