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Article
July 1981

Squamous Cell Carcinomas in Fanconi's Anemia

Author Affiliations

From the Clinique Dermatologique, Hôpital Edouard-Herriot, Lyons France.

Arch Dermatol. 1981;117(7):443-444. doi:10.1001/archderm.1981.01650070071033
Abstract

It has been suggested that the gene responsible for Fanconi's anemia predisposes a person to leukemias as well as to solid tumors.1-2 The latter have been mainly of two types—hepatocellular carcinomas3 and squamous cell carcinomas.4 There have been six described patients with Fanconi's anemia in whom squamous cell carcinomas developed3-7 (Table). The following case report describes the occurrence of multiple squamous cell carcinomas of the vulva in a young woman with Fanconi's anemia.

Report of a Case  A 24-year-old woman had had a diagnosis of Fanconi's anemia made at the age of 9 years. This diagnosis had been based on the following features: a dirty-gray pigmentation of the genital and perigenital regions extending to the inner surface of the thighs, with five cafe-au-lait spots on the trunk and lower limbs; delayed growth, with below normal weight and height; a right ectopic kidney, with a short ureter

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