The relationship between vinyl chloride exposure and human angiosarcoma of the liver has been well reported in the literature. Exposure to arsenic and thorium dioxide has also been associated with angiosarcoma of the liver. In animal experiments using vinyl chloride as a carcinogen, angiosarcoma of nonhepatic tissues including that of the lip and nose has developed.1 However, there is no adequate report of any relationship between exposure to occupational or environmental carcinogens and development of angiosarcoma in nonhepatic tissues in humans. Rubin's point is well taken that we should include a thorough occupational history in any case of angiosarcoma. In the case I described, I did not find any history to suggest exposure to vinyl chloride, arsenic, or thorium dioxide.
Sarma D. Occupational History and Angiosarcoma-Reply. Arch Dermatol. 1981;117(8):453. doi:10.1001/archderm.1981.01650080004006