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August 1981

Tuberous Sclerosis in Twins

Author Affiliations

Varanasi, India

Arch Dermatol. 1981;117(8):456. doi:10.1001/archderm.1981.01650080008014

To the Editor.—  Tuberous sclerosis is a hereditary, neurocutaneous disorder. Its manifestations constitute a triad of adenoma sebaceum, epilepsy, and mental retardation.1 Heredity is evident in approximately one third of the reported cases for which an autosomal dominant gene of variable penetrance is responsible. The remaining cases are attributed to a gene mutation, the frequency of which has been found to be one in 20,000 to one in 50,000.2 The disease is reported herein in twin boys whose family had no history of tuberous sclerosis.

Report of Cases.—Case 1.—  A 7-year-old boy had had lesions on his face at 4 years of age. These gradually increased in number. He had no history of epilepsy, and his general health was good. On examination, his height was 119.5 cm, and his weight was 19 kg. He had multiple, raised, red-brown papules of varying sizes (1 to 4 mm)

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