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August 1981

Premalignant Lymphoid HyperplasiaPreceding and Coexisting With Malignant Lymphoma in the Skin

Author Affiliations

From the Departments of Dermatology, University of Pennsylvania School of Medicine (Drs Shelley and Wood) and Jefferson Medical College (Dr Wilson), and the Department of Radiation Therapy, University of Pennsylvania School of Medicine (Dr Goodman), Philadelphia. Dr Shelley is now with the Peoria School of Medicine, Peoria, Ill.

Arch Dermatol. 1981;117(8):500-503. doi:10.1001/archderm.1981.01650080054029

• A primary malignant lymphoma of the skin had concurrent and antecedent lesions showing histologic changes of completely benign lymphoid hyperplasia. The malignant lymphoma itself evolved during a few years, although specimens from repeated biopsies had previously exhibited benign lymphoid hyperplasia. We urge that persistent benign lymphoid hyperplasia in its many clinical forms in the skin be recognized as a long-term premalignant lesion. Awareness of such a continuum of benign to malignant change aids in the interpretation of the histologic findings in these growths and alerts the clinician to the need for years of careful surveillance. Histologic assessment should indicate whether the specimen shows benign, indeterminate, or malignant change.

(Arch Dermatol 1981;117:500-503)