• A 28-year-old woman had an intensely pruritic eruption, consisting of plaques and vesicobullous lesions, three days after removal of a hydatidiform mole. Direct immunofluorescence (IF) microscopy of involved skin showed the linear deposition of C3 but no immunoglobulin along the basement membrane zone. Indirect IF microscopy disclosed a serum complement-fixing IgG antibody that reacted with the basement membrane of human adult and fetal skin. Thus, herpes gestationis can occur in association with a hydatidiform mole.
(Arch Dermatol 1981;117:510-512)
Tindall JG, Rea TH, Shulman I, Quismorio FP. Herpes Gestationis in Association With a Hydatidiform MoleImmunopathologic Studies. Arch Dermatol. 1981;117(8):510-512. doi:10.1001/archderm.1981.01650080064032