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Article
September 1981

Origin of Plasma Protoporphyrin in Patients With Erythropoietic Protoporphyria-Reply

Arch Dermatol. 1981;117(9):527. doi:10.1001/archderm.1981.01650090007008
Abstract

In Reply.—  Protoporphyrin disappears from RBCs as they age in the blood of living patients with EPP. Rates for this in vivo event were determined by Piomelli et al1 using in vitro procedures. Rates for disappearance of PP from the RBCs of patients with EPP, and, for the appearance of PP in plasma, were determined as the RBCs were incubated with porphyrin-free plasma. Rates for this in vitro event were determined by Piomelli et al1 using in vitro procedures. The subtitle of our report was "I. Different Rates of Disappearance of Protoporphyrin From the Erythrocytes, Both In Vivo and In Vitro."It has been suggested (1) that this use of the term "in vivo" is inappropriate, (2) that I "insist that the studies of Piomelli et al1 were partly in vivo," whereas "this does not constitute in vivo experimentation," and (3) that citation of this work of Piomelli et

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