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September 1981

Cutaneous Manifestations of Leprechaunism

Author Affiliations

From the Departments of Pathology (Dr Roth) and Pediatrics (Drs Schedewie, Herzberg, and Elders), University of Arkansas College of Medicine, Little Rock; the Department of Medicine, University of Colorado School of Medicine, Denver (Dr Olefsky); and the Department of Medicine, University of Chicago School of Medicine (Dr Rubenstein).

Arch Dermatol. 1981;117(9):531-535. doi:10.1001/archderm.1981.01650090013015

• Three patients who had leprechaunism were noted to have cutaneous alterations consistent with acanthosis nigricans. In addition, these patients had hypertrichosis and dysplastic nails. The biochemical hallmarks of this disease are hyperinsulinemia and fasting hypoglycemia. The biochemical findings and an abnormality of insulin binding may be the basis for the development of these characteristic cutaneous lesions.

(Arch Dermatol 1981;117:531-535)