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September 1981

Vesicobullous Dermatosis With Linear Deposition of IgA in a Black Child

Author Affiliations

From the Department of Medicine, University of Tennessee Center for Health Sciences, Memphis.

Arch Dermatol. 1981;117(9):590-592. doi:10.1001/archderm.1981.01650090072032

• An 8-year-old black boy had a vesicobullous eruption characterized by the microscopic linear deposition of IgA at the basement membrane zone. Vesicobullous dermatosis with the linear deposition of IgA can be differentiated from classic dermatitis herpetiformis (DH) and bullous pemphigoid (BP) on the basis of immunofluorescence microscopy findings. Immunologic abnormalities such as the occasional presence of circulating anti-basement membrane zone antibodies and the relatively low prevalence of HLA-B8 antigen suggest that persons with this disease have a fundamentally different pathophysiologic disease process than do persons with DH or BP.

(Arch Dermatol 1981;117:590-592)