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October 1981

Quinidine-lnduced Acne

Author Affiliations

Toledo, Ohio

Arch Dermatol. 1981;117(10):603-604. doi:10.1001/archderm.1981.01650100003003

To the Editor.—  Various drugs can produce a wide variety of reactions in the skin. Certain drugs are capable of aggravating existing acne or inducing acneform eruptions. What I believe to be the first case of quinidine sulfate-induced acne is reported herein.

Report of a Case.—  A papular eruption occurred on the chest and back of a 57-year-old man who had a history of premature ventricular contractions soon after the initiation of therapy with quinidine. The eruption continually worsened during the ensuing year with continuation of the quinidine therapy. The patient was receiving no other oral medications.On physical examination, numerous papulopustules were noted scattered on his back and chest, intermixed with an occasional open and closed comedone. There were no cystic lesions or scars.Quinidine therapy was continued. Topical treatment was initiated with an erythromycin solution and a topical benzoyl peroxide preparation. Excellent resolution of the eruption occurred within

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