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October 1981

Progressive Nodular Histiocytoma

Author Affiliations

From the Dermatology Service (Dr Burgdorf) and the Pathology Service (Dr Pitha), Veterans Administration Hospital; and the Department of Dermatology, University of Oklahoma School of Medicine (Drs Kusch and Nix), Oklahoma City.

Arch Dermatol. 1981;117(10):644-649. doi:10.1001/archderm.1981.01650100046027

• Progressive nodular histiocytoma is a clinically distinct variant in the general group of normolipemic histiocytic proliferations. Its cardinal feature is the presence of two different lesions—a superficial yellow-brown papule and a deep nodule. We describe herein a 29-year-old man with such lesions. Histologically, a variety of fibrous and cellular patterns were seen, mimicking the wide spectrum of findings in ordinary dermatofibromas. On ultrastructural examination, the most striking feature of the preponderant cell was lipid phagocytosis.

(Arch Dermatol 1981;117:644-649)