To the Editor.—
In the July 1980 Archives (116:812-814), Kumar et al state that intercellular deposits of complement are not found in the perilesional skin of patients with pemphigus. They use this observation to support their suggestion that pemphigus antibodies can be distinguished from pemphigus-like antibodies by the inability of the former to fix complement.There are, however, a number of published reports of intercellular deposits of complement in the skin of patients with pemphigus.1,2 To determine how commonly such deposits occur, I have recently reviewed the results of direct immunofluorescent microscopic studies performed on 22 patients with pemphigus seen in the Department of Dermatology, Bullous Disease Clinic, New York University School of Medicine. All patients had pemphigus by clinical, histologic, and immunofluorescent microscopic criteria. Intercellular deposits of C3 were present in ten (45%) of the patients (Figure). In all but one patient, C3 was present in association with intercellular deposits of IgG or IgM.
Bystryn J. Intercellular Deposits of Complement in Skin of Patients With Pemphigus. Arch Dermatol. 1981;117(11):682. doi:10.1001/archderm.1981.01650110004002