To the Editor.—
Polymorphonuclear leukocytes (PMNLs) phagocytose and kill bacteria.1 Phagocytosis is accompanied by a burst of oxygen (O2) consumption that generates large amounts of superoxide anion (.O2-)) and hydrogen peroxide (H2O2), which are responsible for bacterial killing.1Chronic granulomatous disease (CGD)2 is a disorder involving high susceptibility to bacterial infection because of the inability of patients' PMNLs to convert O2 into.O2and H2O2 and to kill some types of bacteria, despite normal phagocytosis and degranulation.1,2In most reported cases,2 the onset of the disease occurs soon after birth (when the patient is younger than 3 years of age) with major signs of localized or disseminated infection. We wish to draw attention to the possibility of late onset of the disease with mild skin lesions only, as we observed in a girl and her brother.
Barriere H, Litoux P, Stalder J, Buriot C, Hakim J. Chronic Granulomatous Disease: Late Onset of Skin Lesions Only, in Two Siblings. Arch Dermatol. 1981;117(11):683-684. doi:10.1001/archderm.1981.01650110005005