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November 1981

Autosomal Recessive Prolidase DeficiencyThree Patients With Recalcitrant Leg Ulcers

Author Affiliations

From the Divisions of Dermatology (Drs Ogata, Tanaka, and Tomoda) and Psychiatry (Dr Murayama), National Kumamoto Hospital, Kumamoto, Japan; the Department of Pediatrics, Kumamoto University Medical School (Dr Endo), Kumamoto, Japan; and the Department of Dermatology, Miyazaki Medical College (Dr Kikuchi), Miyazaki, Japan.

Arch Dermatol. 1981;117(11):689-694. doi:10.1001/archderm.1981.01650110011009

• Three patients had prolidase deficiencies. The family pedigree of these three patients suggests that this rare disorder is inherited through an autosomal recessive gene. This genodermatosis is characterized by a number of signs and symptoms referable to the skin, CNS, teeth, ears, nose, throat, eyes, bones, and joints. Among the skin changes, recalcitrant leg ulcers are the most characteristic. At this time, there is no established method of treatment of this rare disorder, but the use of dapsone was helpful in the treatment of one of our patients.

(Arch Dermatol 1981;117:689-694)