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November 1981

Etretinate in the Treatment of Juvenile Pityriasis Rubra Pilaris

Author Affiliations

From the Department of Dermatology, Universitäts-Hautklinik, Münster, West Germany.

Arch Dermatol. 1981;117(11):749-750. doi:10.1001/archderm.1981.01650110071026

Oral retinoids have been reported to be effective in the treatment of pityriasis rubra pilaris (PRP).1,2 These compounds are far less toxic than vitamin A, although vitamin A is still recommended for the treatment of PRP by some authors.3 We report herein favorable results obtained with etretinate therapy in two children with PRP.

Report of Cases 

Case 1.—  An 8-year-old girl had had PRP since the age of 5 years. The disease had started with small patches of follicular hyperkeratosis on the arms. Despite treatment with 0.1% triamcinolone acetonide and 0.1% betamethasone valerate, the dermatitis had progressively involved more and more areas of the body. On physical examination, large patches of follicular hyperkeratosis and erythema with central hypopigmentation affected about 50% of the body surface, including the face and scalp. The palms and soles showed erythema and scaling, and multiple pits were present in the fingernails. The diagnosis

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