Oral retinoids have been reported to be effective in the treatment of pityriasis rubra pilaris (PRP).1,2 These compounds are far less toxic than vitamin A, although vitamin A is still recommended for the treatment of PRP by some authors.3 We report herein favorable results obtained with etretinate therapy in two children with PRP.
Report of Cases
An 8-year-old girl had had PRP since the age of 5 years. The disease had started with small patches of follicular hyperkeratosis on the arms. Despite treatment with 0.1% triamcinolone acetonide and 0.1% betamethasone valerate, the dermatitis had progressively involved more and more areas of the body. On physical examination, large patches of follicular hyperkeratosis and erythema with central hypopigmentation affected about 50% of the body surface, including the face and scalp. The palms and soles showed erythema and scaling, and multiple pits were present in the fingernails. The diagnosis
Fleissner J, Happle R. Etretinate in the Treatment of Juvenile Pityriasis Rubra Pilaris. Arch Dermatol. 1981;117(11):749-750. doi:10.1001/archderm.1981.01650110071026