Keratoderma palmaris et plantaris encompasses a group of hereditary disorders whose common feature is notable thickening of the stratum corneum of the palms and soles. The most common form is tylosis, which is an autosomal dominant genodermatosis. It develops soon after birth, with thickening of the palms and soles, and usually reaches maximum severity by the age of 6 months. Thickening of the keratin layer is diffuse but is strictly limited to these sites. The condition persists throughout life and may become accentuated by chronic friction and repeated trauma.1 Our case illustrates the superimposition of Trichophyton rubrum infection on this condition.
Report of a Case
A 42-year-old man had had tylosis since birth and had been observed off and on for 23 years. Genealogic study had shown that his paternal grandmother, his father, one sister, two of his five children, and one granddaughter were all similarly affected. The records
Mikhail GR, Babel D. Trichophyton rubrum Infection and Keratoderma Palmaris et Plantaris. Arch Dermatol. 1981;117(11):753-754. doi:10.1001/archderm.1981.01650110075029