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December 1981

Wells' Syndrome: Recurrent Granulomatous Dermatitis With Eosinophilia

Author Affiliations

Medford, Ore

Arch Dermatol. 1981;117(12):759. doi:10.1001/archderm.1981.01650120005006

To the Editor.—  Wells and Smith1 described 12 cases of a distinctive eosinophilic cellulitis showing acute cutaneous swellings followed by indolent infiltration. The clinical picture is associated with an equally striking histologic picture of focal phagocytosis of eosinophilic material in the dermis. Spigel and Winkelmann2 have added two additional cases from the United States. I believed it important to bring this additional case to your readers' attention.

Report of a Case.—  In 1966, a 39-year-old woman was bitten by a spider on the left axilla. Within hours, an urticaria-like eruption appeared on her left arm and face. This was followed by recurrent bouts of generalized urticaria-like plaques. At first, the eruption was responsive to oral corticosteroids administered by her family physician. When the lesions recurred and persisted despite treatment, she was referred for further evaluation of her condition. She came to us for examination six weeks after being bitten.

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