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December 1981

Bullous Amyloidosis

Author Affiliations

From the Departments of Pathology (Dr Westermark) and Dermatology (Drs Öhman and Domar), University Hospital, Uppsala, Sweden; and the Institute of Biochemistry, University of Oslo, Norway (Dr Sletten).

Arch Dermatol. 1981;117(12):782-784. doi:10.1001/archderm.1981.01650120028015

• The distribution pattern of amyloid deposition varies greatly in systemic amyloidosis. In primary and myeloma-associated amyloidosis, skin manifestations are common. Three patients with myeloma-associated amyloidosis had bullae or signs of increased skin fragility caused by cleavage in extensive dermal amyloid deposits. The bullae in bullous amyloidosis are, therefore, unique since they are intradermal, not subepidermal.

(Arch Dermatol 1981;117:782-784)