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December 1981

Epidermal Keratinocyte Differentiation and Fibrillogenesis, vol 9: Frontiers of Matrix Biology

Author Affiliations

Palo Alto, Calif

Arch Dermatol. 1981;117(12):817. doi:10.1001/archderm.1981.01650120063029

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That the dermal matrix plays a critical role in determining the pattern of epidermal cell differentiation is now well established. This volume is an attempt, largely by European investigators, to present an up-to-date review of some of the more recent and important issues in the interactions of keratinocytes with the extracellular matrix. The subjects covered are somewhat loosely related and include such topics as the growth and differentiation of adult human epidermal cells on dermal substrates, new antibodies to detect keratinocyte differentiation, morphologic and biochemical criteria for keratinization in mouse epidermal cell cultures, keratinization and the plasma cell membrane of the stratum corneum cell, synthesis of the keratohyalin granule, basement membrane formation, the microfilaments of the basement membrane, and a review of collagen, laminin, and fibronectin present at the dermal-epidermal junction.

A new approach to the culture of human keratinocytes is to use the basal lamina directly for the attachment

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