• Studies of keratinization in several harlequin fetuses have shown different abnormalities, suggesting that the disorder may have different causes. The histologie appearance, x-ray diffraction pattern, and fibrous polypeptide composition of the epidermis from two new cases of the harlequin fetus were found to differ from each other as well as from previously reported cases. Epidermal cells of one of the new cases were successfully cultured and showed large numbers of lysosomes. These findings support the hypothesis that the disease may have multiple causes.
(Arch Dermatol 1982;118:14-18)
Baden HP, Kubilus J, Rosenbaum K, Fletcher A, Studies •. Keratinization in the Harlequin Fetus. Arch Dermatol. 1982;118(1):14-18. doi:10.1001/archderm.1982.01650130018010