• The effect of 1,000 mg of tetracycline hydrochloride and 200 mg of minocycline hydrochloride on Propionibacterium acnes levels and skin-surface lipid levels was measured in 15 patients with acne. Minocycline produced a significantly greater reduction in the P acnes counts that persisted even up to three weeks after discontinuation of the minocycline therapy, in contrast to the return of P acnes to baseline counts within three weeks after discontinuation of the tetracycline therapy. A similar persistence of effect for reduction of skin-surface free fatty acid levels and clinical lesions was also seen with minocycline therapy.
(Arch Dermatol 1982;118:19-22)
Leyden JJ, McGinley KJ, Kligman AM. Tetracycline and Minocycline TreatmentEffects on Skin-Surface Lipid Levels and Propionibacterium acnes. Arch Dermatol. 1982;118(1):19-22. doi:10.1001/archderm.1982.01650130023011