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February 1982

Treatment of Psoriasis With Plasmapheresis

Author Affiliations


Arch Dermatol. 1982;118(2):74. doi:10.1001/archderm.1982.01650140006005

To the Editor.—  The editorial by Anderson in the February 1981 Archives (117:67-68) on dialysis treatment of psoriasis certainly sustains the hope for severely disabled patients with psoriasis who do not respond to conventional therapy. Furthermore, it indicates the importance of a humoral factor or factors somehow involved in the pathogenesis of psoriasis. Immunologic factors may also be pathogenetically involved. The recovery of circulating stratum corneum antibodies1 and epidermal cell nuclear antibodies2 and the demonstration of deposits of immunoglobulin and C3 by immunofluorescent microscopy in psoriatic lesions3 corroborate this view.Dau4 reported the remission of concomitant psoriasis in a patient undergoing plasmapheresis for myasthenia gravis. In addition to the removal of low molecular substances, as in dialysis, plasmapheresis would also eliminate proteins with potential immunologic pathogenetic importance.Consequently, we decided to perform plasmapheresis in a 54-year-old man with recalcitrant psoriasis of eight years' duration. Since 1977,

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