• Three patients with pyoderma gangrenosum were treated with suprapharmacologic doses of methylprednisolone sodium succinate using a five-day pulse therapy regimen. This therapy produced a dramatic remission with minimal side effects. The effects of pulse therapy are reviewed, and its role in severe steroid-responsive dermatoses is discussed.
(Arch Dermatol 1982;118:76-84)
Johnson RB, Lazarus GS. Pulse TherapyTherapeutic Efficacy in the Treatment of Pyoderma Gangrenosum. Arch Dermatol. 1982;118(2):76-84. doi:10.1001/archderm.1982.01650140008008