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February 1982

Blockade of Carcinoid Flush With Cimetidine and Clonidine

Author Affiliations

From the Department of Dermatology, University of Texas Medical School, Houston.

Arch Dermatol. 1982;118(2):109-111. doi:10.1001/archderm.1982.01650140041017

• A patient with the carcinoid syndrome had flushes provoked by the ingestion of water at 60 °C, red wine, and milk chocolate. The patient was given sequential courses of clonidine hydrochloride, chlorpheniramine maleate, cimetidine, and a combination of chlorpheniramine and cimetidine. No flushes followed ingestion of red wine or milk chocolate during treatment courses with cimetidine (alone or in combination with chlorpheniramine) or clonidine. Chlorpheniramine alone did not affect flushing. None of the pharmacologic agents altered the flushing response to the ingestion of water at 60 °C.

(Arch Dermatol 1982;118:109-111)