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April 1982

Fanconi's AnemiaTumor-like Warts, Hyperpigmentation Associated With Deranged Keratinocytes, and Depressed Cell-Mediated Immunity

Author Affiliations

From the Departments of Dermatology (Drs Johansson and Niemi) and Pediatrics (Dr Siimes), Helsinki University Central Hospital; and the Department of Virology, University of Helsinki (Dr Pyrhönen).

Arch Dermatol. 1982;118(4):249-252. doi:10.1001/archderm.1982.01650160039020

• A 27-year-old man had had Fanconi's anemia (FA) for 20 years. The patient had pancytopenia, retarded growth, hypogonadism, and chromosomal aberrations. He had freckle-like and darker pigmented macules scattered on his chest, shoulders, upper part of the back, and hips, with interspersed, hypopigmented areas. Biopsy specimens taken from both the hyperpigmented and hypopigmented spots showed a derangement of keratinocytes and nuclear abnormalities, more notable on sunexposed skin sites. The patient also had numerous tumor-like, recalcitrant, viral warts. Immunologic studies showed normal humoral immunity, but there was evidence of depressed cell-mediated immunity. We speculate that the chromosomal aberrations, the depressed cell-mediated immunity, and the increased frequency of malignant neoplasms known to occur in patients with FA also reflect changes related to an increased susceptibility to viral infections.

(Arch Dermatol 1982;118:249-252)