April 1982

Neutrophilic Eccrine HidradenitisA Distinctive Type of Neutrophilic Dermatosis Associated With Myelogenous Leukemia and Chemotherapy

Author Affiliations

From the Departments of Pathology (Drs Harrist, Murphy, and Mihm) and Dermatology (Drs Fine, Berman, and Mihm) and the Dermatopathology Unit (Drs Harrist, Murphy, and Mihm), Massachusetts General Hospital and Harvard Medical School, Boston.

Arch Dermatol. 1982;118(4):263-266. doi:10.1001/archderm.1982.01650160053024

• On two occasions, erythematous edematous plaques developed on the left side of the neck and the left shoulder of a man undergoing induction chemotherapy for acute myelogenous leukemia. The lesions resolved after several days in both instances. Histologically, numerous neutrophils surrounded and focally infiltrated the eccrine secretory coils, in which epithelial necrosis was observed. The "fixed" nature of the plaques and temporal relationship to chemotherapy suggest that the lesions represent an unusual reaction to chemotherapeutic agents. It is possible that this unique clinicopathologic picture represents a neutrophilic dermatosis associated with leukemia.

(Arch Dermatol 1982;118:263-266)