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April 1982

Congenital Self-healing HistiocytosisClinical, Histologic, and Ultrastructural Study

Author Affiliations

From the Clinics of Dermatology (Drs Bonifazi and Meneghini) and Pediatrics (Dr Ceci), University of Bari, Italy; and the Clinic of Dermatology, Institute of Pharmacology, University of Milan, Italy (Dr Caputo).

Arch Dermatol. 1982;118(4):267-272. doi:10.1001/archderm.1982.01650160057025

• In a typical case of congenital self-healing histiocytosis of the Hashimoto-Pritzker type, the results of an ultrastructural examination of a nodule of a 30-day-old patient showed that about 25% of the cells contained Langerhans' granules and that approximately 40% of the cells contained unique phagosomes but no regularly laminated bodies. This case of congenital self-healing histiocytosis is an example of concurrent proliferation of two types of histiocytes (one with and one without Langerhans' granules). Since transitional forms were not observed, this finding might indicate the existence of congenital, self-healing forms of histiocytosis X.

(Arch Dermatol 1982;118:267-272)