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June 1982

Darier's Disease and Vitamin AConcentrations of Retinoids in Serum and Epidermis of Untreated Patients

Author Affiliations

From the Department of Dermatology, University of Uppsala, Uppsala, Sweden. Dr Lee is currently affiliated with Yonsei University, Seoul, South Korea.

Arch Dermatol. 1982;118(6):389-392. doi:10.1001/archderm.1982.01650180023010

• Blood samples and skin biopsy specimens from 13 male patients with Darier's disease (DD) and 11 healthy male controls were analyzed for carotene, retinol (vitamin A1), dehydroretinol (vitamin A2), and retinol-binding protein (RBP). The serum carotene level was lower in the patients than in the controls, but the vitamin A and RBP levels did not differ from those of the controls regardless of the severity of the disease. The RBP could be visualized by immunofluorescence microscopy in the epidermis of both unaffected and lesional skin of patients with DD. In the epidermis of patients with DD (uninvolved and lesional), the carotene content was similar to that of the controls. The retinol content was probably higher than in the controls. By contrast, the dehydroretinol concentration was normal in the uninvolved skin but markedly higher than normal in the lesions, especially in the severe cases. The abnormal distribution of retinoids in DD may reflect localized disturbances of epidermal vitamin A metabolism rather than a defect in serum vitamin A transport.

(Arch Dermatol 1982;118:389-392)