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June 1982

Familial Occurrence of Pemphigus Vulgaris

Author Affiliations

From the Division of Dermatology, University of California Los Angeles (UCLA) School of Medicine.

Arch Dermatol. 1982;118(6):423-424. doi:10.1001/archderm.1982.01650180057018

• Two families with pemphigus vulgaris were observed. In one family, cutaneous and mucous membrane pemphigus developed in a mother and daughter within a nine-year interval. In the other family, pemphigus developed in a brother and sister simultaneously. The diagnosis was confirmed immunopathologically in all four patients. Clinical disease did not develop in the other family members. Studies in families with pemphigus can provide further understanding of genetic and environmental factors involved in the pathogenesis of pemphigus.

(Arch Dermatol 1982;118:423-424)