• Two families with pemphigus vulgaris were observed. In one family, cutaneous and mucous membrane pemphigus developed in a mother and daughter within a nine-year interval. In the other family, pemphigus developed in a brother and sister simultaneously. The diagnosis was confirmed immunopathologically in all four patients. Clinical disease did not develop in the other family members. Studies in families with pemphigus can provide further understanding of genetic and environmental factors involved in the pathogenesis of pemphigus.
(Arch Dermatol 1982;118:423-424)
Ahmed AR, Sofen H. Familial Occurrence of Pemphigus Vulgaris. Arch Dermatol. 1982;118(6):423-424. doi:10.1001/archderm.1982.01650180057018