• 1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. This report delineates the enhancement of penetration of clindamycin phosphate, erythromycin base, fusidate sodium, fluorouracil, desonide, amcinonide, and triamcinolone acetonide. For this purpose 1-dodecylazacycloheptan-2-one can be used in concentrations as low as 1%. It is colorless, relatively odorless, nontoxic, and can be applied neat to human skin without any irritation.
(Arch Dermatol 1982;118:474-477)
Stoughton RB. Enhanced Percutaneous Penetration With 1-Dodecylazacycloheptan-2-one. Arch Dermatol. 1982;118(7):474-477. doi:10.1001/archderm.1982.01650190028013