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Article
August 1982

Blue-Red Macules and Pseudoatrophic MaculesAdditional Cutaneous Signs in Neurofibromatosis

Author Affiliations

From the Department of Dermatology, University of Amsterdam (Dr Westerhof); and the Department of Dermatology, University of Vienna (Dr Konrad).

Arch Dermatol. 1982;118(8):577-581. doi:10.1001/archderm.1982.01650200045014
Abstract

• Blue-red macules and pseudoatrophic macules are characteristic skin lesions of neurofibromatosis that have been infrequently mentioned in the recent literature. The histologic characteristics of the blue-red macules show thick-walled blood vessels located mainly in the papillary dermis and often overlying subcutaneous neurofibromatous tissue. The histologic characteristics of the pseudoatrophic macules show a reduction in collagen in the reticular dermis, with diffuse replacement by neuroid tissue. These clinical signs can be detected early in the course of the disease and are useful in establishing an early diagnosis.

(Arch Dermatol 1982;118:577-581)

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