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August 1982

Pilar Neurocristic HamartomaIts Relationship to Blue Nevus and Equine Melanotic Disease

Author Affiliations

From the Department of Pathology, Cleveland Clinic Foundation (Dr Tuthill); the Departments of Dermatology and Pathology, Hospital of the University of Pennsylvania, Philadelphia (Dr Clark); and the Department of Histopathology, Royal Marsden Hospital, London (Dr Levene). Read in part before the semiannual meeting of the Dermatopathology Club, St Louis, Sept 17, 1978.

Arch Dermatol. 1982;118(8):592-596. doi:10.1001/archderm.1982.01650200060018

• A unique pigmented lesion, judged to be a hamartoma of neural crest origin, occurring in a female patient, is compared with equine melanotic disease. The characteristic perifollicular arrangement of pigment-laden spindle cells is remarkably similar in both. Previously described patch- and plaque-like blue nevi in humans are also closely related. Light and ultrastructural features showed differentiation toward both nevus cells and Schwann cells, and it is proposed that the lesion be termed pilar neurocristic hamartoma.

(Arch Dermatol 1982;118:592-596)