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August 1982

Lymphadenoid Structure Induced by Gold Hypersensitivity

Author Affiliations

From the Department of Dermatology, Hamamatsu University School of Medicine, Japan.

Arch Dermatol. 1982;118(8):608-611. doi:10.1001/archderm.1982.01650200076023

† An allergic sensitivity to gold earrings produced a lymphadenoid reaction with germinal centers in the dermis of the pierced earlobes of a 21-year-old woman. However, a patch test for 1% gold sodium thiomalate gave a long-lasting, clinically and histologically eczematous response. Electron microscopic and cytochemical observations showed that non-T lymphocytes and plasma cells were dominant in the dermal infiltrate of the lesions, whereas lymphocytes with convoluted nuclei (which were probably T cells) and monocytes invaded the epidermis in the patch test site. These findings suggest that continuous exposure of the dermis to gold in a sensitized person may induce a lymphadenoid cellular reaction different from the histologic findings seen after contact with the epidermis.

(Arch Dermatol 1982;118:608-611)