[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.176.107. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 1982

Clinical Significance of Autoantibodies in Pemphigus

Author Affiliations

BOSTON

From the Department of Dermatology, Tufts University School of Medicine and the New England Center Hospitals, Boston.

Arch Dermatol. 1982;118(10):837-843. doi:10.1001/archderm.1982.01650220141021
Abstract

Single determinations of antibodies by means of immunofluorescent (IF) staining were performed on the sera of 35 patients with pemphigus. Antibodies were present in the serum of all 23 patients with active pemphigus. There was a correlation between the level of antibody titers and the activity of the disease.

Serial determinations were performed on the sera of four patients with widespread lesions of pemphigus while they were being treated with high doses of corticosteroids. In three patients the antibodies disappeared with clearing of the lesions although one of them had a mild relapse and a low (doubtful) antibody titer four months later. The fourth patient had complete clearing of his lesions on two occasions with a decrease in antibody titers. Both times the clearing was followed by a relapse and a rise of the antibody titer.

×