Concepts that account for disease manifestations are necessarily seen in terms of the kind of science in vogue at the moment. At the peak of interest in the cell cycle, a decade or longer ago, patterns of mitotic replication were studied in a number of epithelial disorders. The information obtained from these studies gave a new kind of understanding to these disorders.
From time to time, it is important to reexamine all the fundamentals of a disease in an attempt to improve the prevailing concepts. A reexamination of the ichthyoses in such a framework may be timely now. Some new areas of information may provide new clues to the nature of the disorders themselves as well as to other disorders in which disturbed keratinization is a major determinant of disease expression, including such disparate diseases as dry skin, keratoses, warts, and acne.
The singular aspect of the diseases known as
Van Scott EJ, Yu RJ. Commentary: Ichthyosis and KeratinizationConcepts in Transition. Arch Dermatol. 1982;118(10):860-861. doi:10.1001/archderm.1982.01650220164024